Mohamed Salah's hattrick fired Liverpool to the top of the Premier League with an impressive 4-0 win at Bournemouth, while Manchester United also finally hit some free-scoring form with a 4-1 win over Fulham at Old Trafford on Saturday.
Arsenal extended their unbeaten run to 21 games, but left it late to beat Huddersfield 1-0 thanks to Lucas Torreira's overhead kick seven minutes from time.
Salah had been rested from the start for Wednesday's 3-1 win at Burnley that kept Jurgen Klopp's men on City's coat-tails, and the Egyptian looked to have benefited from a break as he looked more like the player who netted 44 goals in an incredible debut season at Anfield.
The visitors were slightly fortunate to take the lead on 25 minutes when Asmir Begovic fumbled Roberto Firmino's long-range shot Salah's follow-up effort was allowed to stand despite him appearing to be marginally offside.
Salah made the game safe by showing determination to stay on his feet despite being fouled before finding the bottom corner early in the second-half.
Steve Cook's own goal then made it 3-0 before Salah sealed his hattrick by remaining remarkably cool to dribble past Begovic twice before prodding home.
“What Mo did around his two goals in the second half was just exceptional," said Klopp. "I don't know at the moment a lot of players who would have scored these two goals."
Jose Mourinho again rang the changes, but continued to leave Paul Pogba on the bench.
And it was three of those introduced to the side from Wednesday's 2-2 draw with Arsenal that scored in the first-half with Ashley Young, Juan Mata and Romelu Lukaku on target.