Leverkusen, the Bundesliga champions who have also reached the May 25 German Cup final, played their 49th match without defeat in all competitions, surpassing Benfica's long-standing European record set from 1963 to 1965.
Atalanta's passage to the Dublin final, where they will face Bayer Leverkusen, later this month was fully deserved after a dominant performance in which Marseille barely had a kick in yet another poor away display from the Ligue 1 outfit.
Xabi Alonso's Leverkusen, who have 40 wins in their unbeaten run, face Atalanta in the May 22 final in Dublin after the Italians comfortably got past Olympique Marseille.
Xabi Alonso's rampaging Bayer Leverkusen will have an additional incentive in Thursday's home second-leg Europa League semifinal against Roma: breaking a 59-year-old European football record.
Erik ten Hag insists he is the man to revive embattled Manchester United after they hit a new low against Crystal Palace. But will he even be there for the FA Cup final?
Leverkusen's superiority was fully on display.
"Disappointed that we did not go through but not frustrated or angry. Now we can focus on the league and that's what we will do," Klopp told reporters.
Last season's runners-up Roma advanced to their fourth European semi-final in a row.
Atalanta have a chance to make history on Thursday as they welcome Liverpool to Bergamo with one foot in the Europa League semi-finals thanks to a stunning first-leg win at Anfield.
Manchester United avoided further embarrassment after their humiliating defeat to Manchester City by coming from behind to beat Cypriots Omonia Nicosia 3-2 in the Europa League on Thursday, while Premier League leaders Arsenal eased past Bodo/Glimt.
Jadon Sancho and Cristiano Ronaldo gave timely reminders of their value with both on target as Manchester United got their Europa League campaign back on track with a 2-0 victory at Moldovan side Sheriff Tiraspol on Thursday.
Manchester United kicked off their Europa League campaign poorly with a 1-0 home defeat by Real Sociedad as Arsenal's new signing Marquinhos scored in a 2-1 win at FC Zurich on Thursday.
Chelsea hammered their London rivals Arsenal 4-1 to win the Europa League thanks to two goals from Eden Hazard, possibly making his last appearance for the Blues, and one apiece for Olivier Giroud and Pedro.
Manchester United's Paul Pogba takes a step towards helping repay his world record transfer fee with the opening goal in their Europa League win over Ajax Amsterdam.
Though he denies it, Manchester United manager Jose Mourinho has gambled the club's season on the outcome of Wednesday's Europa League final against Ajax in Stockholm.
Ajax Amsterdam produced a performance worthy of the club's illustrious past when they crushed Olympique Lyonnais 4-1 on Wednesday to move to the brink of their first European final since 1996.
Manchester United striker Zlatan Ibrahimovic has vowed to come back even stronger after suffering a serious knee injury against Anderlecht in Europa League last week.
Manchester United manager Jose Mourinho said he was preparing for bad news after losing Zlatan Ibrahimovic and Marcos Rojo to injury during his side's Europa League quarterfinal success against Anderlecht.
At least seven football fans were killed and 11 injured when an electric cable fell on a building where they were watching a Europa League match, Nigerian police said Friday.