Josip Stanisic scored in the seventh minute of stoppage time as Bayer Leverkusen extended their unbeaten run to 45 games in all competitions with a 1-1 draw at Borussia Dortmund on Sunday.
Former winners Dortmund will next face Paris Saint-Germain for a place in the final.
Antoine Griezmann said Atletico Madrid will have to "suffer" at Borussia Dortmund to reach the Champions League semi-finals.
The duo are the underdog sides remaining in this season's quarter-finals, with the other six teams either among the elite
Donyell Malen scored a superb goal against his former side but a second-half penalty from Luuk de Jong earned a 1-1 draw for PSV Eindhoven in the first leg of their Champions League last-16 tie against Borussia Dortmund at the Philips Stadion on Tuesday.
English winger Jadon Sancho said he was "welcomed like family" after returning to Borussia Dortmund from Manchester United.
Borussia Dortmund CEO Hans-Joachim Watzke shot down suggestions the returned Jadon Sancho was difficult to manage, saying the England winger "has no problems with discipline".
Jadon Sancho rejoined Borussia Dortmund on loan for the rest of the season on Thursday, less than three years since Manchester United paid £73 million ($93 million, 85 million euros) for the England winger.
Borussia Dortmund will spend the night atop the Bundesliga table for the first time since the penultimate round of last season, winning 3-1 at Hoffenheim on Friday despite finishing with 10 men.
The 29-year-old Austrian vice-captain has undergone a medical and signed a contract until June 2027, his new club announced.
Borussia Dortmund's dream of their first Bundesliga title in 11 years turned into a nightmare on Saturday after a shock 2-2 home draw to Mainz 05 dropped them to second place on goal difference in the season finale, handed the title to rivals Bayern Munich.
Two points clear atop the table, Dortmund can win their first title for 11 seasons by beating Mainz at home on Saturday, regardless of second-placed Bayern Munich's result at Cologne.
Both the German FA (DFB) and the referee in question on Saturday admitted a mistake in not awarding a penalty to Borussia Dortmund as they dropped potentially crucial points in a 1-1 draw at Bochum.
Bundesliga leaders Borussia Dortmund have extended captain Marco Reus' contract by one year until the summer of 2024, the club announced on Thursday.
Sebastien Haller and Marco Reus both scored twice as Borussia Dortmund thrashed Cologne 6-1 on Saturday, sending the home side top of the Bundesliga ahead of Bayern Munich.
Borussia Dortmund sporting director Sebastian Kehl on Wednesday said the club wants to hold onto English teen star Jude Bellingham "for a long time".
Borussia Dortmund striker Sebastien Haller on Friday scored three goals in eight minutes in his side's 6-0 pre-season friendly victory over Basel as he continued his comeback from testicular cancer.
Anthony Modeste scored four minutes into added time as Dortmund fought back to snatch a 2-2 home draw with Bayern Munich on Saturday.
Werder Bremen fought back from two goals down in the 89th minute to claim a remarkable 3-2 victory at Borussia Dortmund on Saturday, with Scottish forward Oliver Burke scoring the winner.