Years of negotiations culminated early yesterday with countries agreeing the text of a landmark accord on how to tackle future pandemics, aimed at avoiding the mistakes made during the Covid-19 crisis.

After more than three years of talks and one last marathon session, weary delegates at the World Health Organization's headquarters finally sealed the deal at around 2:00 am (0000 GMT) yesterday.

"Tonight marks a significant milestone in our shared journey towards a safer world," said WHO chief Tedros Adhanom Ghebreyesus.

Five years after the emergence of Covid-19, which killed millions of people, devastated economies and upturned health systems, a sense of urgency hung over the talks, with new threats lurking -- including H5N1 bird flu, measles, mpox and Ebola.

The final stretch of the talks also took place under the shadow of cuts to US foreign aid spending and threatened tariffs on pharmaceuticals.

Right until the last minute, disagreement lingered over a few thorny issues.