Tottenham Hotspur put aside their woeful domestic season with a 3-1 home victory against Norway's Bodo/Glimt leaving them within sight of the Europa League final on Thursday.
Bruno Fernandes struck twice as Manchester United put one foot in the Europa League final with a clinical away performance to beat 10-man Athletic Bilbao 3-0 on Thursday.
Manchester United were drawn Friday to play Real Sociedad of Spain in the last 16 of this season's Europa League, while Rangers will take on Jose Mourinho's Fenerbahce, and Tottenham Hotspur face AZ Alkmaar.
Former winners Porto were drawn Friday to face Claudio Ranieri's Roma in the standout tie of the Europa League knockout phase play-offs, while Manchester United and Tottenham Hotspur were among the clubs to discover their potential opponents in the last 16.
Manchester United manager Erik ten Hag has highlighted a lack of goals as the major factor behind the English giants' faltering start to the season.
Erik ten Hag made a convincing case to be spared the sack as Manchester United upset Manchester City to take the FA Cup with a shock 2-1 victory in Saturday's final.
Bayer Leverkusen's Florian Wirtz has been voted Player of the Season in the Bundesliga, the German League said on Monday, after the midfielder helped his club in winning their first league title.
Bayer Leverkusen stretched their season-long unbeaten run to 50 games with a 5-0 win at 10-man Bochum on Sunday.
Xabi Alonso's rampaging Bayer Leverkusen will have an additional incentive in Thursday's home second-leg Europa League semifinal against Roma: breaking a 59-year-old European football record.
Atalanta stunned Anfield as Gianluca Scamacca scored twice in a 3-0 win on Thursday to leave Liverpool with a mountain to climb to reach the Europa League semi-finals.
Brighton's "incredible" journey from homeless exiles facing oblivion to their current status as Premier League trendsetters will reach a memorable climax when they host AEK Athens in their first-ever European match on Thursday.
AS Roma coach Jose Mourinho said he was not fixated on becoming a legend at the club after leading his side to a second straight European final with a 1-0 aggregate win over Bayer Leverkusen after their Europa League semi-final, second leg on Thursday.
Europa League thoroughbreds Sevilla recovered to reach another final as substitute Erik Lamela'sfabulous header five minutes into extra time earned a gritty 2-1 win in a pulsating affair against Juventus on Thursday, securing a 3-2 aggregate victory.
AS Roma grabbed a 1-0 home victory over Bayer Leverkusen in their Europa League semi-final first leg on Thursday thanks to 20-year-old Edoardo Bove's second-half goal.
Federico Gatti scored with a header seven minutes into added time to earn Juventus a 1-1 home draw against Sevilla in their Europa League semi-final first leg on Thursday.
Liverpool will take the chance to qualify for the Europa League as they look to squeeze everything out of a disappointing season, manager Juergen Klopp said ahead of Sunday's home Premier League game against Tottenham Hotspur.
Manchester United coach Erik ten Hag said his players lacked passion and desire in their 3-0 thrashing by Sevilla in the Europa League on Thursday.
Bayer Leverkusen eased into the Europa League semi-finals after crushing hosts Union Saint-Gilloise of Belgium 4-1 on Thursday for a 5-2 aggregate win that stretched their unbeaten run to 12 straight matches across all competitions.
Stephan El Shaarawy and Lorenzo Pellegrini scored in extra time to earn hosts AS Roma a spot in the Europa League semi-finals after defeating Dutch side Feyenoord 4-1 on Thursday for a 4-2 aggregate win.