Newcastle goalkeeper Nick Pope will be sidelined for "around four months" with a shoulder injury, manager Eddie Howe said on Wednesday as his list of absentees continued to grow.
Newcastle must avoid defeat in the French capital to have any chance of reaching the last 16
"We had to come here, Chelsea, to show that it's going to be difficult for them to play, to win the game and to beat us," said Pochettino
Newcastle United striker Alexander Isak netted on his return from injury, while two quick-fire second-half goals and a late Anthony Gordon strike gave the Magpies a 4-1 Premier League win over 10-man Chelsea at St James' Park on Saturday.
United had suffered five defeats in their previous 10 home games this season, their worst start to a campaign at Old Trafford since 1930-31 when they also lost five of 10 and were relegated from the top flight.
Mikel Arteta branded Arsenal's 1-0 defeat at Newcastle "a disgrace" after Anthony Gordon's winner was controversially allowed to stand by VAR.
Manchester United manager Erik ten Hag looked shell-shocked as his team were booed off the pitch and the Dutchman is under intense pressure following their 3-0 defeat by Manchester City at Old Trafford on Sunday.
A rampant Newcastle United put in a stellar showing to secure a superb 4-1 victory over French champions Paris St Germain in their first Champions League home match in 20 years on Wednesday.