Stefano Pioli is close to guaranteeing Milan, in second, a spot in Europe's top club competition in what will almost certainly be his final season at the club
France's record goal scorer Olivier Giroud has reached agreement with Los Angeles FC to join the Major League Soccer club this summer, sources close to the player confirmed on Tuesday.
Goals from Francesco Acerbi and Marcus Thuram gave Inter a 17-point advantage over closest challengers Milan and secured their 20th league crown with five matches of the season remaining.
Last season's runners-up Roma advanced to their fourth European semi-final in a row.
Noah Okafor salvaged a hard-fought point for Milan in the 84th minute on a hot spring day in Reggio Emilia, but second-placed Milan still risk conceding the Scudetto to Inter in a hotly-anticipated derby despite coming back from two goals down.
AC Milan strolled past 10-man Lecce 3-0 on Saturday to consolidate second place in Serie A and take another step towards Champions League qualification.
AC Milan's owners said on Thursday they will build a 70,000-capacity new stadium for the seven-time European champions that will serve as a multi-purpose venue.
Marcus Thuram was key to Inter's win at a soaking Stadio Olimpico in Rome as, with his team trailing at half-time, the France attacker made it two goals each shortly after the break and forced the Angelino own goal which put Inter ahead in the 56th minute.
The fixture was stopped in the 16th minute in honour of Maignan's shirt number while a famous King quote was displayed on the San Siro's big screens.
Khvicha Kvaratskhelia helped put Napoli's Serie A title defence back on track with a brace in Saturday's 3-1 win at Verona which moved the champions four points behind leaders AC Milan.
Inter rebounded from their first loss of the season midweek against Sassuolo thanks to a sensational second-half display from Martinez.
Portugal winger Leao netted his third goal in as many league matches in the eighth minute at a sodden San Siro to move Milan up to second on 12 points from five games
Newcastle held AC Milan to a goalless draw in Tuesday's opening match of their first Champions League campaign in two decades.
Stefano Pioli insisted on Monday that AC Milan have turned their attentions to the Champions League opener with Newcastle United after the local derby humiliation at the weekend.
Inter Milan laid down an early title marker on Saturday by handing out a 5-1 derby hammering to AC Milan and going it alone at the Serie A summit, while champions Napoli were held 2-2 at promoted Genoa.
Italy's Milan giants face off in Saturday's local derby which pits Serie A's form teams against one another in a match which will give an early indication of their title credentials..
Paris St Germain will kick off their quest for a maiden Champions League trophy in a strong Group F featuring Borussia Dortmund, AC Milan and Newcastle United following the draw on Thursday.
The 24-year-old is looking to give his club career a jump start at Milan after being sold by Chelsea and he was key to Stefano Pioli's side claiming the points in their opening match of the season
AC Milan, the football club which won a host of domestic and European titles under Silvio Berlusconi's ownership, called him "unforgettable" in a tribute after his death aged 86 Monday.