Why are you here?

Iran will not negotiate with the West over its presence in the Middle East, Supreme Leader Ayatollah Ali Khamenei said, days after the visiting French foreign minister sought to discuss Tehran's role in regional conflicts.

Jean-Yves Le Drian travelled to Tehran on Monday with a brief to reaffirm Europe's support for a nuclear deal that opened Iran's economy while echoing US concern about Tehran's missile programme and its influence in the region.

"European countries come (to Tehran) and say we want to negotiate with Iran over its presence in the region. It is none of your business. It is our region. Why are you here?" Khamenei was quoted as saying by his official website.

Khamenei said Iran would only negotiate on that issue with other states in the region.

"We will negotiate with America, when we wanted to be present in America," he added.

US President Donald Trump has threatened to pull out of the nuclear deal unless three European signatories help "fix" the accord by forcing Iran to limit its sway in the Middle East and rein in its missile programme.

French President Emmanuel Macron has criticised the programme and raised the possibility of new sanctions.

Tehran supports Syria's President Bashar al-Assad in the government's war against rebel forces, including groups backed by the West, and is an ally of Israel's enemy Hezbollah in Lebanon.

Iran has one of the Middle East's largest missile programmes and some of its precision-guided missiles have the range to strike Israel.

Israeli Prime Minister Benjamin Netanyahu discussed Tehran's military activities in the region with Trump in Washington this week.

Iran has also been aiding the Shia-led government of Iraq in its fight against the Sunni militant Islamic State group.