Rafa bites the Dustin

Rafael Nadal was sent crashing out of Wimbledon by dread-locked German qualifier Dustin Brown on Thursday, his fourth successive humiliation at the All England Club.

Nadal, the 2008 and 2010 champion, slumped to a 7-5, 3-6, 6-4, 6-4 second round defeat against the world number 102 who hit 13 aces and 58 winners.

It was the 29-year-old's first ever defeat to a qualifier at a Grand Slam and came in the aftermath of losing his French Open crown where he had been champion nine times.

The loss followed his 2012 second round exit to world 100 Lukas Rosol, a first round beating by the 135-ranked Steve Darcis in 2013 and last year's fourth round defeat to Nick Kyrgios, who was at 144.

Down at his lowest ranking for a decade -- at 10 in the world -- Thursday's defeat was yet another symptom of the great Spaniard's game being in a terminal state of decline.

For Brown, who once drove to tournaments in a camper van to save money, it was his second win against Nadal having won on grass in Halle in 2014.

"I had actually never been on Centre Court before," said Brown.

"They asked me before the match if I wanted to go on the court. I didn't know what was going to happen, so I just said I'll just go on when I play."

Earlier, former champions Roger Federer and Andy Murray swept into the third round as a fourth player from the women's top 10 tumbled out of the tournament.

Seven-time winner and second seed Federer eased to a 6-4, 6-2, 6-2 win over Sam Querrey of the United States, the world number 36 who has now lost all three times he has played the Swiss and has yet to win a set.

Third seed Murray, the 2013 champion, was equally dominant, taking just one minute longer than Federer to reach the third round by seeing off Robin Haase, the world number 78 from the Netherlands, 6-1, 6-1, 6-4.

Women's defending champion Petra Kvitova reached the third round with a 6-2, 6-0 win over Japan's Kurumi Nara in a Court One little-and-large tussle.

Second seed Kvitova will face Serbian 26th seed Jelena Jankovic, who dispatched Russia's Evgeniya Rodina 6-7 (4/7), 6-1, 6-3.

Former world number one Caroline Wozniacki made the third round with a 6-1, 7-6 (8/6) win over Denisa Allertova, the world number 83 from the Czech Republic.

German 10th seed Angelique Kerber was also a winner, seeing off Russia's Anastasia Pavlyuchenkova 7-5, 6-2 while 2012 runner-up Agnieszka Radwanska, the Polish 13th seed, defeated Australia's Ajla Tomljanovic 6-0, 6-2.

However, the women's draw opened up even further when Russian eighth seed Ekaterina Makarova, a quarterfinalist in 2014, went down 6-2, 7-5 to unseeded Magdalena Rybarikova of Slovakia.

Before this tournament, the world number 65 Rybarikova had never won a match at Wimbledon in seven years of trying.