Nadal, Del Potro in last eight
Defending champion Rafael Nadal on Sunday reached the US Open quarterfinals for the eighth time where he will face Dominic Thiem, one of only three men to defeat him in 2018.
World number one Nadal saw off a battling Nikoloz Basilashvili, the first Georgian in a fourth round in New York, 6-3, 6-3, 6-7 (6/8), 6-4.
Elsewhere, Juan Martin del Potro, the 2009 champion, beat Borna Coric 6-4, 6-3, 6-1 to make the last-eight for a third successive year.
The third seeded Argentine will next face John Isner, the last American man standing, who defeated Milos Raonic 3-6, 6-3, 6-4, 3-6, 6-2, taking his tournament aces total past the 100-mark.
Thiem, who beat Nadal on clay in Madrid in the run-up to Paris, booked his place in the quarterfinals for the first time with a 7-5, 6-2, 7-6 (7/2) win over 2017 runner-up Kevin Anderson.
Six-time champion Serena Williams survived a spirited challenge from unseeded Kaia Kanepi to triumph 6-0, 4-6, 6-3 and reach the quarterfinals of the US Open.
Williams booked a quarterfinal date with Karolina Pliskova, the eighth-seeded Czech who beat Australian Ashleigh Barty 6-4, 6-4.
Defending champion Sloane Stephens, the third seed, eased past Elise Mertens 6-3, 6-3 to book a quarterfinal rematch with Latvian Anastasija Sevastova.