Inadequate sequencing of SARS-CoV-2 variants impedes global response

The lack of sequencing of SARS-CoV-2 variants is imperilling the global response to the COVID-19 pandemic, argues Dana Crawford of Case Western Reserve University in a new Viewpoint published recently in the journal PLOS Genetics.

Surveillance is essential to a successful and rapid response to disease outbreaks, but public health surveillance has traditionally focused on monitoring case numbers, hospitalisations and deaths. Advances in genome sequencing now allow us to track genetic variation in evolving viruses in unprecedented detail.

Crawford cites insufficient funding, the lack of an effective sample tracking system and strict regulations on sample and data sharing as the causes of the inadequate sequencing efforts. She cautions that investments in SARS-CoV-2 genomics need to continue and expand as new variants will likely arise due to variability in vaccination rates and adherence to COVID-19 precautions worldwide.

Crawford concludes that ongoing international sequencing efforts are still needed to understand and respond to this continually evolving virus that knows no international boundaries.