Djokovic said that his subdued performance on a court where he has won six titles might have been due to the blow suffered while greeting fans on Friday night.
Djokovic's bid for a record-extending 41st Masters 1000 title was ended in just over an hour by Chilean Tabilo, who is ranked 32nd in the world but was hugely impressive and claimed his first win over a top-10 opponent.
Defeat to seventh seed Hurkacz casts doubt over whether clay-court icon Nadal will play at the upcoming French Open, where he has won a record 14 titles.
"I have Roland Garros in just two weeks and a half... I need to prove myself if I am able to push my body to the limit, I need to push to feel myself ready for what's coming," Nadal told reporters.
The 22-time Grand Slam singles champion has recently returned to the circuit after a long absence due to injury.
Rublev, who takes the Madrid crown from double champion Carlos Alcaraz whom he beat in the quarter-finals, said he had played despite feeling ill at times this week and hailed his doctors for helping him through.
Coming back from 1-3 down in the decider and saving three match points in total, Swiatek claimed a 7-5, 4-6, 7-6 (9/7) victory to secure the Madrid Open trophy for the first time.
Rublev upset home favourite Alcaraz 4-6, 6-3, 6-2 to reach the semi-finals.
Spaniard Carlos Alcaraz says he will form a dream team with his legendary compatriot Rafael Nadal in the men's doubles at the Paris Olympics later this year "if everything goes well."
The 22-time Grand Slam title winner, back on court this week after three months on the sidelines, battled well but eventually crumbled against the hard-working world number 11 from Australia.
The 22-time Grand Slam champion had not played a competitive match since January but eased past the 62nd-ranked Cobolli in 85 minutes to reach the second round.
The 12th-ranked Greek, who will return to top 10 on Monday, also won the title in the principality in 2021 and 2022.
"First training... with the hope of being here these days before the start of the tournament. I'm here to see how it goes... with the desire to try to play," wrote Nadal on social media, alongside a picture of the Spaniard sitting courtside with his rackets.
Rafa Nadal's withdrawal from the Monte Carlo Masters has cast doubt over the 22-times Grand Slam champion's participation at the French Open, but Novak Djokovic said he is still hoping for a final chapter in their storied rivalry.
"Unfortunately I have to tell you that I am not going to be playing in Monte Carlo. My body simply won't allow me," said the battle-weary Spaniard on social media.
Jannik Sinner said he is enjoying every moment of his sensational start to the 2024 season after winning the Miami Open on Sunday for his third title of the year.
Novak Djokovic and Goran Ivanisevic are to go their separate ways, the tennis world number one announced on Wednesday, ending a five-year association which yielded 12 Grand Slams.
The emotion of the game itself, a missed chance for a third straight win in a tournament for the first time in over a year, was enhanced by Murray knowing this week was his final appearance in a city he calls his "tennis home".
Sabalenka's partner, Belarusian former NHL ice hockey player Konstantin Koltsov, 42, died late Monday after jumping from the balcony of a room in an upmarket resort in Miami, police said.