Djokovic said that his subdued performance on a court where he has won six titles might have been due to the blow suffered while greeting fans on Friday night.
Djokovic's bid for a record-extending 41st Masters 1000 title was ended in just over an hour by Chilean Tabilo, who is ranked 32nd in the world but was hugely impressive and claimed his first win over a top-10 opponent.
Defeat to seventh seed Hurkacz casts doubt over whether clay-court icon Nadal will play at the upcoming French Open, where he has won a record 14 titles.
Novak Djokovic was left in agony after being struck with a hard plastic water bottle as he left the court following his 6-3, 6-1 win over France's Corentin Moutet at the Rome Open which advanced him to the third round on Friday.
"I have Roland Garros in just two weeks and a half... I need to prove myself if I am able to push my body to the limit, I need to push to feel myself ready for what's coming," Nadal told reporters.
World number one Novak Djokovic said he believes he will be in top form for the French Open and hopes to prove that at the Italian Open which started on Wednesday.
The 22-time Grand Slam singles champion has recently returned to the circuit after a long absence due to injury.
Rublev, who takes the Madrid crown from double champion Carlos Alcaraz whom he beat in the quarter-finals, said he had played despite feeling ill at times this week and hailed his doctors for helping him through.
Coming back from 1-3 down in the decider and saving three match points in total, Swiatek claimed a 7-5, 4-6, 7-6 (9/7) victory to secure the Madrid Open trophy for the first time.
Rublev upset home favourite Alcaraz 4-6, 6-3, 6-2 to reach the semi-finals.
Last month, the Serb ended a five-year partnership with coach Goran Ivanisevic.
Spaniard Carlos Alcaraz says he will form a dream team with his legendary compatriot Rafael Nadal in the men's doubles at the Paris Olympics later this year "if everything goes well."
On the women's side, Iga Swiatek was made to sweat in her 4-6, 6-0, 6-2 victory over Brazilian lefty Beatriz Haddad Maia, as she dropped her first set of the tournament and needed two and a half hours to reach a second consecutive Madrid semi-final.
"Now I'm enjoying. Let's see how I wake up tomorrow. Playing at home means everything to me, just try my best to keep dreaming."
Nadal's reward is a last-16 clash with the 30th-seeded Jiri Lehecka on Tuesday.
Jabeur, the 2022 Madrid champion, took a swipe at tournament organisers, telling reporters she believes tennis still has a way to go to achieve gender equality, despite it being the leader in women's sport.
"Today was the test of fire, no discomfort, feeling spectacular... from here, we'll be getting better."
Masfia Afrin from Bangladeshi received the ITF White Badge School certificate following an exam held from 24-28 April in Kuala Lumpur, Malaysia.