US Open winner Dominic Thiem swept into the last 16 at Roland Garros on Friday along with women's top seed Simona Halep and third seed Elina Svitolina.
Thiem broke down early resistance from Norway's Casper Ruud to secure an impressive 6-4, 6-3, 6-1 victory and set up a possible showdown with 2015 French Open winner Stan Wawrinka.
"I'm very happy. It was a great match and I didn't do any mistakes," said Thiem, the runner-up to Nadal the past two years.
"The conditions are very nice to play in under the roof - no wind and the court is perfect."
Halep extracted brutal revenge on American teenager Amanda Anisimova with a 6-0, 6-1 victory to move ominously into the fourth round.
Anisimova caused a huge upset last year when she beat Romanian Halep, then the defending champion, but could not reproduce that form. Halep was in typically miserly mood, giving precious little away and waiting for mistakes.