Five-time European champions Liverpool will aim to finish off eternal rivals Manchester United when England's two most successful sides clash in the Europa League last 16, second leg at Old Trafford on Thursday.

Leading 2-0 from the first leg at Anfield, Liverpool are well placed to reach the quarterfinals of a competition that realistically represents the best chance for either club to qualify for next season's Champions League.

Borussia Dortmund will seek to protect a 3-0 lead as they head to Tottenham Hotspur on the back of their biggest win against an English side.

Spurs paid the price for resting Harry Kane and leaving Mousa Dembele and Erik Lamela on the bench as they were outclassed by Thomas Tuchel's German title challengers.

Gary Neville's Valencia must overcome a 1-0 deficit at home to fellow Spanish outfit Athletic Bilbao.

The former Manchester United and England defender was furious after his side crashed to a 1-0 defeat against local rivals and La Liga's bottom side Levante over the weekend.

Holders Sevilla return to Spain following a goalless draw against Swiss champions Basel, whose St-Jakob Park will stage this year's final, as they continue their quest for a fifth title in the past decade.

Villarreal go to Bayer Leverkusen with a 2-0 advantage from the first leg, while 2009 champions Shakhtar Donetsk head to Anderlecht following a 3-1 victory in Ukraine.

Fenerbahce take a narrow 1-0 lead to Portuguese side Braga, while Lazio, who were charged by UEFA for racist chanting after last week's 1-1 draw in the Czech Republic, return home for their second leg against Sparta Prague.