Tottenham's winless run in the Premier League stretched to four games as Mauricio Pochettino's men threw away an early lead through Harry Kane to lose 2-1 at Southampton on Saturday.
Dele Alli made his return after seven weeks out with a hamstring injury and the England international duo combined to great effect for Kane's opener on 26 minutes.
Kane freed Alli in behind the Southampton defence and he then returned the favour to pick out the England captain at the back post, who controlled and slotted low past Angus Gunn for his 200th career goal.
However, Spurs wastefulness in failing to add to their lead came back to cost them as Southampton improved after the break and secured a vital three points in their attempt to beat the drop.
Fresh from scoring his first professional goal away to Manchester United last weekend, right-back Yan Valery levelled from Stuart Armstrong's cross.
James Ward-Prowse then completed the comeback with a stunning free-kick curled into the top corner to leave Hugo Lloris helpless.