The number of new confirmed coronavirus cases crossed the grim milestone of one million and the death toll topped 50,000 yesterday.
The virus claimed thousands more lives in its relentless march across the globe, including nearly 1,000 new deaths in Spain, despite measures putting more than half of the planet on some form of lockdown.
And it continued to wreak havoc on the global economy, with the US announcing that a record 6.65 million workers filed for unemployment benefits last week and Spain reporting its biggest monthly increase in jobless claims ever.
Since emerging in China in December, COVID-19 has infected more than 10,00,000 people -- including at least 500,000 in Europe -- and claimed more than 50,000 lives, according to a tally by AFP from official sources.
The crisis has put enormous strain on national health care systems and on nurses, doctors and other medical staff working in the most difficult of circumstances.
"Every morning before I start work, I make the sign of the cross, and pray that everything will go all right," Ester Piccinini, a 27-year-old nurse at the Humanitas Gavazzeni hospital in Bergamo, northern Italy, told AFP.
"It's not really for myself, I'm not really worried about me, since I'm so protected. But I hope everything will be all right for my patients."
Europe has been at the centre of the crisis for weeks, with at least 34,000 now dead, but there have been signs the epidemic could be approaching its peak.
Spain yesterday said it had suffered a record 950 deaths in 24 hours, bringing its total number of fatalities to 10,003.
The number of confirmed Spanish cases passed the 110,000 mark, the government said, although the rates of both new infections and deaths continued a downward trend.
"The data show the curve has stabilised" and the epidemic has entered a "slowdown" phase, Health Minister Salvador Illa said.
Italy has also seen its infection rates slow and eyes will now be on Britain and France, which both reported their highest daily death tolls on Wednesday.
The virus has chiefly affected the elderly and those with pre-existing medical conditions, but recent cases have highlighted that it can kill people of all ages.
British Prime Minister Boris Johnson, himself in isolation after testing positive, announced plans for a massive increase in virus testing after it emerged that just 2,000 of hundreds of thousands of staff in the state-run National Health Service (NHS) had been tested.
In Russia, President Vladimir Putin extended a period of paid non-working days until the end of April as the number of confirmed cases jumped by more than a quarter to 3,548, with 30 deaths.
Most of the Russian population is on lockdown, with Moscow in particular facing tough isolation rules.
Thailand became the latest country to impose strict measures with the introduction of a curfew from today, pushing the number of people in confinement to 3.9 billion, or half the world's population.
The United States, which now accounts for almost a quarter of reported global infections, saw its death toll pass 5,000 by the early hours of yesterday, according to a tally by Johns Hopkins University.
Among the latest known US fatalities was a six-week-old baby who was taken to a Connecticut hospital late last week.
"Testing confirmed last night that the newborn was COVID-19 positive," the state's Governor Ned Lamont tweeted. "This is absolutely heartbreaking."
US President Donald Trump, who was criticised for initially playing down the virus but has stepped up containment efforts, warned that the situation was going to get much worse.
"We're going to have a couple of weeks, starting pretty much now, but especially a few days from now, that are going to be horrific," he said.
"But even in the most challenging of times, Americans do not despair. We do not give in to fear."
Around 85 percent of Americans are under confinement but there have been warnings of a staggering US death toll, even with mitigation efforts in force.
Yesterday, the US disaster response agency FEMA asked the American military for 100,000 body bags.
The virus and the measures taken to contain it have raised fears of the worst global economic downturn since the Great Depression of the 1930s.
The US Labour Department yesterday said that the figure of 6.65 million workers who filed for unemployment benefits last week was double the number registered in the previous week, and the most ever recorded.
Economists are warning that US job losses could surge to the previously unimaginable range of 10 to 20 million in April.
Spain, the eurozone's fourth-largest economy, also registered a leap of 302,265 jobless claims last month after imposing a nationwide lockdown since March 14.
French Finance Minister Bruno Le Maire yesterday urged European nations to "go further and act stronger" to help each other's economies recover from crisis.
"In this crisis... either Europe stays true to its political roots and it will thrive, or Europe gives in to panic and national selfishness and it will disappear," Le Maire said in a press conference broadcast via Twitter.
He reiterated France's call for a common fund to help EU countries kickstart an economic recovery and bolster healthcare capacities over five to 10 years.
Financial ratings agency Fitch yesterday predicted that the US and eurozone economies would contract this quarter by up to 30 percent on an annualised basis, as struggling businesses slash investment and widespread unemployment dampens consumer spending.