Croatia's Ajla Tomljanovic made history in the French Open on Friday by upsetting third seed Agnieszka Radwanska of Poland 6-4, 6-4 in the third round.
The defeat meant that the tournament's top three seeds had all been ousted inside six days, with top seed Serena Williams losing in the second round and second seed Li Na departing in the first.
It was the first Grand Slam in the Open era where the top three women seeds all failed to make the last 16.
Fourth seed Simona Halep of Romania is the top seeded player left in the draw, having reached the third round on Thursday.
Playing later in the day, seventh seed Maria Sharapova of Russia dodged the debris to inflict a 6-0, 6-0 thrashing on hapless Paula Ormaechea of Argentina. In what was a total mismatch on the Roland Garros centre-courts, Sharapova won 54 points to 17 for her opponent with the South American taking just three points in the second set as her resistance to the onslaught crumbled.
Men's Second seed Novak Djokovic made the fourth round with a tough 6-3, 6-2, 6-7 (2/7), 6-4 win over Croatia's Marin Cilic.
Djokovic, the 2012 runner-up, next faces either French 13th seed Jo-Wilfried Tsonga or Poland's Jerzy Janowicz, the 22nd seed, for a place in the quarterfinals.
Roger Federer, the fourth seeded 2009 champion, reached the last 16 with a 7-5, 6-7 (7/9), 6-2, 6-4 win over Russia's Dmitry Tursunov.
Federer will play Latvia's Ernests Gulbis for a place in the quarterfinals.
Tomljanovic ended 2013 ranked 78th in the world, improving from 495th - the biggest ranking improvement by any player in the top 100.
This year she lost in the third round at the Australian Open but more recently failed to qualify for the main draw at Madrid and Rome in the buildup to Roland Garros.
For Radwanska it was the first time she had failed to make it past the third round at a Grand Slam event since the 2012 French Open.
Last year she was a semi-finalist at Wimbledon, a quarter-finalist at the Australian and French Opens and made the fourth round at the US Open.