Novak Djokovic and Andy Murray stayed on course for a mouth-watering US Open quarter-final showdown Saturday as five-time women's champion Serena Williams stood alone as America's last singles title hope.
But as the heavyweights of the sport eased into the fourth round, the women's draw was blown open again when Wimbledon champion Petra Kvitova became the fifth top 10 seed to exit in the first week.
Kvitova's misery was shared by American tennis after John Isner and Sam Querrey were both knocked out in the third round leaving the hosts still without a men's Grand Slam champion since Andy Roddick triumphed in New York in 2003.
Djokovic, the 2011 champion, brushed aside Querrey for the eighth time in nine meetings, with a 6-3, 6-2, 6-2 win taking the world number one into the fourth round at a major for the 22nd consecutive time.
"Sam is big server, very powerful. But he doesn't move that well so I wanted to keep him moving around the court, mix up the pace and get as many returns as possible back," said Djokovic after an 85-minute win which was never in doubt from the time he raced into a 5-0 lead in the first set.
Wimbledon champion and seven-time major winner Djokovic will next face Germany's Philipp Kohlschreiber who ended US hopes with a 7-6 (7/4), 4-6, 7-6 (7/2), 7-6 (7/4) win over Isner despite the American 13th seed firing 42 aces and 77 winners.
It was the third successive year that Kohlschreiber had defeated Isner in the third round.
"It's a disappointment for me personally, not the United States as a whole," said Isner.
Williams racked up her 75th victory at the US Open when she eased past her third successive American compatriot, Uzbekistan-born left-hander Varvara Lepchenko, 6-3, 6-3 and will tackle tough Estonian Kaia Kanepi for a quarterfinal berth.
"I had to make some adjustments because of the wind but I got some excellent advice from my coach," said 32-year-old Williams, playing in her 15th US Open and aiming to become just the second woman after Chris Evert in the 1970s to win three New York titles in succession.
"My opponent played at an unbelievable level but I tried to hang in there and do what I needed to do."
Murray, the 2012 champion, hit 47 winners in a 6-1, 7-5, 4-6, 6-2 victory over Russia's Andrey Kuznetsov, the world 96, to book a seventh appearance in the fourth round and goes on to face French ninth seed Jo-Wilfried Tsonga who beat Pablo Carreno-Busta of Spain, 6-4, 6-4, 6-4.
Third seeded Stan Wawrinka, the Australian Open champion, reached the fourth round without hitting a ball when Slovenian opponent Blaz Kavcic withdrew with a right foot injury.
That took the number of retirements and walkovers at this year's US Open to 10 in the men's event and two in the women's.
Wawrinka next faces 16th-seeded Spaniard Tommy Robredo, a 3-6, 6-3, 7-6 (7/4), 6-3 winner over Australian Nick Kyrgios, who had shocked Rafael Nadal in the fourth round at Wimbledon.