After securing a slot in the Champions League last 16 in mid-week, Manchester United will look to drive home their advantage in the Premier League when they visit Aston Villa on Saturday.
United moved to the top of the pile by beating Arsenal 2-1 last weekend and with nearest rivals Chelsea and Manchester City both in action on Sunday, victory at Villa Park would put Alex Ferguson's men four points clear.
Having beaten Chelsea and Arsenal in their last two league outings, United now embark upon a kinder run of fixtures that includes a trip to Norwich City before home games against QPR and West Ham.
Wednesday's 3-1 win over Braga in Portugal means Ferguson can afford to rest players in United's two remaining Champions League group games, so the domestic title race will now be the number one priority.
Villa are just one place above the relegation zone, and United striker Wayne Rooney says his side should show no mercy as they bid to stretch their lead at the summit.
(1500GMT unless otherwise stated)
Wigan Athletic v West Bromwich Albion, Southampton v Swansea City, Stoke City v Queens Park Rangers, Reading v Norwich City, Everton v Sunderland, Arsenal v Fulham, Aston Villa v Manchester United (1730GMT)
Manchester City v Tottenham Hotspur (1330GMT), Newcastle United v West Ham United, Chelsea v Liverpool (1600GMT)