The TV series highlights the fighting spirit present in all humans. The protagonist of the story, Neel, a young girl from an affluent family, is abducted and taken to a jungle. Neel Nirjon-e is the story of Neel's journey back home. Throughout the journey she is surprised at the trust complete strangers bestow her with and is also devastated when her trusts are played with.

Richi Solaiman, Jayanta Chattopadhyay, Fazlur Rahman Babu, Wahida Mallick Jolly, Ahmed Rubel and Azad Abul Kalam play the central roles in the serial.